Resources

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– Prof. Jorge Manzanares Robles Miguel Hernández University (UMH), Alicante, Spain – Prof. Jan Rodriguez Parkitna Maj Institute of Pharmacology, PAS, Kraków, Poland – Prof. Maria Salud Garcia-Gutiérrez Miguel Hernández University (UMH), Alicante, Spain – Prof. Francisco Navarrete Rueda Miguel Hernández University (UMH), Alicante, Spain – Prof. Daniela Navarro Miguel Hernández University (UMH), Alicante, Spain – Michał Marczyk, PhD Silesian University of Technology, Gliwice, Poland; Yale University, New Haven, USA – Łukasz Wróbel, PhD Silesian University of Technology, Gliwice, Poland – Prof. Roman Morawski Warsaw University of Technology, Warszawa, Poland – Sylwia Grubarek Maj Institute of Pharmacology, PAS, Kraków, Poland – Bohdan Widła, PhD Jagiellonian University, Kraków, Poland

Lecture Description

TrePsy Benzodiazepines Conference was held in Conference Hall, Severo Ochoa Building, Universidad Miguel Hernández, San Juan de Alicante, Alicante, Spain on11th April 2025. The main topic od the Conference is focused on contemporary issues associated with the use of benzodiazepines in therapy, including the possibility of using cannabinoids to alleviate the effects of chronic benzodiazepine use.

Lecture Description

Opening Ceremony Speakers: Vicente Micol, Vice-Chancellor of International Relations, Universidad Miguel Hernández, Spain; Jan Rodríguez Parkitna, Coordinator TrePsy Project, Deputy Director for Research, Maj Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland; Jorge Manzanares, Coordinator of the Spanish site of TrePsy Project, Full Professor of Pharmacology, Instituto de Neurociencias, Universidad Miguel Hernández, Spain.

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Speaker 1: Rafael Maldonado, Full Professor of Pharmacology, Department of Medicine and Live Sciences, Neuropharmacology Laboratory Research Group, Universidad Pompeu Fabra, Barcelona, Spain. RIAPAd Benzodiazepines pharmacology. Speaker 2: Jorge Manzanares, Coordinator of the Spanish site of TrePsy Project, Full Professor of Pharmacology, Instituto de Neurociencias, Universidad Miguel Hernández, Spain. RIAPAd Clinical uses of benzodiazepines.

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Speaker 1: Joan Villalbí, Delegate of the Spanish National Plan on Drugs, Spanish Ministry of Health, Spain. The problem of benzodiazepines in Spain. Speaker 2: Jose Augusto Pochapski, Central Intitute of Mental Health, Mannheim Prevalence and harms of benzodiazepines in Europe.

Lecture Description

Speaker 1: María Salud García Gutiérrez, Associate Professor of Pharmacology, Instituto de Neurociencias, Universidad Miguel Hernández, Spain. RIAPAd GABAA receptor subtypes in the regulation of pharmacological actions of benzodiazepines. Speaker 2: Jorge Manzanares, Coordinator of the Spanish site of TrePsy Project, Full Professor of Pharmacology, Instituto de Neurociencias, Universidad Miguel Hernández, Spain. RIAPAd Cannabinoid mediated regulation of benzodiazepines.

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Speaker 1: Sonia Álvarez Sesmero, Psychiatrist, Hospital 12 de Octubre, Madrid, Spain. How to aboid abuse or dependence of benzodiazepines Speaker 2: Marta Marín Mayor, Psychiatrist, Hospital 12 de Octubre, Madrid, Spain. RIAPAd Treatment of benzodiazepines dependence.

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Speaker 1: Gonzalo Herradón Gil-Gallardo, Full Professor of Pharmacology, Universidad San Pablo CEU, Madrid, Spain. RIAPAd Orexines and more. Speaker 2: Francisco Navarrete Rueda, Associate Professor of Pharmacology, Instituto de Neurociencias, Universidad Miguel Hernández, Spain. RIAPAd CBD-mediated regulation of benzodiazepines withdrawal.

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Concluding Remarks of the TrePsy Benzodiazepines Conference

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The Bordeaux Twinning TrePsy Workshop was organised by the Neurocentre Magendie (23rd -27th September 2024). The main topic of the School was “In vivo & in vitro recording of neuronal basis of physiological and pathological behaviors in rodents”. The course included theoretical lectures by leading researchers in the field as well as 3 hands-on workshops: 1) In vivo bulk Ca2+ and DA imaging using fiber photometry – operant behavior; 2) In vivo Ca2+ imaging – miniscope – operant behavior; 3) In vitro bioenergetics – mitochondrial respiration – alteration by cannabinoids.

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The brain, broadly speaking, is for control. 600 million years of evolution has endowed nervous systems with a multitude of mechanisms for achieving that control. In vertebrates, mechanisms in the spinal cord and hindbrain are responsible for more automatized forms of control: reflex circuits, central pattern generators, and circuits for movement primitives. These processes can be selected amongst, modulated, and chained together by the descending influence of brain systems positioned more rostrally that possess a rich capacity to learn from experience. It is these more adaptive systems that my laboratory is most interested in understanding. And yet, control by these systems appears to be fundamentally both heterarchical, requiring distinct computations performed by specific brain systems, and hierarchical, with each system operating at varying degrees of abstraction in relation to the immediate physical world. In this talk, I will describe how experiments in my laboratory focused on understanding how neural circuits are provided a temporal basis computation have revealed not only fundamental principles underlying temporal processing, but also signatures of how hierarchies of representations can interact to produce robust policies for behavior, and how distinct aspects of behavioral control appear to be handled by different brain systems.

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Twinning TrePsy Winter School 2024 – Welcome & Introduction

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Dr. Akseli Graf is passionate about the intersection of artificial intelligence and science. He is interested in the ethical dimensions of artificial intelligence and large language models (LLM) in scientific research, in particular exploring how artificial intelligence can revolutionize scientific workflows and improve the quality of life of scientists through intelligent automation and efficiency. His goal is to bridge the gap between advanced technology and ethical research practices, supporting a more innovative, transparent and accountable research community.

Lecture Description

Francisco Navarrete Rueda is an associate professor at the Department of Pharmacology, Pediatrics and Organic Chemistry, Miguel Hernandez University (UMH). He develops his scientific activity in the laboratory of Translational Neuropsychopharmacology of Psychiatric and Neurological Disorders at the Institute of Neurobiology (UMH-CSIC). His lines of research focus on examining changes in components of the endocannabinoid system to identify potential biomarkers and evaluate its therapeutic use to improve the treatment of several brain disorders, particularly drug addiction.

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Jorge Manzanares is a Professor of Pharmacology at the Department of Pharmacology of the Miguel Hernandez University (UMH) and a principal investigator at the Instituto de Neurociencias of the CSIC and UMH. His research focuses on the involvement of the endocannabinoid signaling in neuropsychiatric disorders and addiction, with the overreaching goal of identifying new and effective treatments.

Lecture Description

Dr Giovanni Marsicano is a tenured researcher at Inserm. He leads the group “Endocannabinoids and Neuroadaptation” at the NeuroCentre Magendie, an INSERM and University of Bordeaux Research Center devoted to neuroscience. Dr. Marsicano is member of the SfN, the French Society of Neuroscience, the International Cannabinoid Research Society (ICRS), and he has been recently elected at EMBO and at FRM (Fondation de la Recherche Medicale). He received, among others, the IACM Young Investigator Award (2007), the Bettencourt-Schuller Price (2008), the Grand Prix Robert Debré (2015), and the prestigious Grand Prix Lamonica for Neurobiology (2021).

Lecture Description

The lecture was given during the Summer School: Translational Addiction Research – A Systems Oriented Approach: From Genes to Brain to Behavior that was held between 15-21 August 2023 in Germany. The event was organised by Zentralinstitut für Seelische Gesundheit as a part of the Twinning_TrePsy project.

Lecture Description

The lecture was given during the Summer School: Translational Addiction Research – A Systems Oriented Approach: From Genes to Brain to Behavior that was held between 15-21 August 2023 in Germany. The event was organised by Zentralinstitut für Seelische Gesundheit as a part of the Twinning_TrePsy project.

Lecture Description

The lecture was given during the Summer School: Translational Addiction Research – A Systems Oriented Approach: From Genes to Brain to Behavior that was held between 15-21 August 2023 in Germany. The event was organised by Zentralinstitut für Seelische Gesundheit as a part of the Twinning_TrePsy project.

Lecture Description

The lecture was given during the Summer School: Translational Addiction Research – A Systems Oriented Approach: From Genes to Brain to Behavior that was held between 15-21 August 2023 in Germany. The event was organised by Zentralinstitut für Seelische Gesundheit as a part of the Twinning_TrePsy project.

Lecture Description

Dra. Maria Salud García-Ayllón – Principal Investigator of the research group “Altered molecular mechanism in Alzheimer’s disease and other neurogenerative diseases” in FISABIO-Instituto de Neurociencias with a broad experience in Alzheimer’s research. The research group is dedicated to the study of neurodegenerative diseases that includes basic investigators and clinicians of the Hospital.

Lecture Description