Bordeaux TrePsy Workshop 2024 – In vivo & in vitro recording of neuronal basis of physiological and pathological behaviors in rodents

The Bordeaux Twinning TrePsy Workshop was organised by the Neurocentre Magendie (23rd -27th September 2024). The main topic of the School was “In vivo & in vitro recording of neuronal basis of physiological and pathological behaviors in rodents”. The course included theoretical lectures by leading researchers in the field as well as 3 hands-on workshops: 1) In vivo bulk Ca2+ and DA imaging using fiber photometry – operant behavior; 2) In vivo Ca2+ imaging – miniscope – operant behavior; 3) In vitro bioenergetics – mitochondrial respiration – alteration by cannabinoids.

The brain, broadly speaking, is for control. 600 million years of evolution has endowed nervous systems with a multitude of mechanisms for achieving that control. In vertebrates, mechanisms in the spinal cord and hindbrain are responsible for more automatized forms of control: reflex circuits, central pattern generators, and circuits for movement primitives. These processes can be selected amongst, modulated, and chained together by the descending influence of brain systems positioned more rostrally that possess a rich capacity to learn from experience. It is these more adaptive systems that my laboratory is most interested in understanding. And yet, control by these systems appears to be fundamentally both heterarchical, requiring distinct computations performed by specific brain systems, and hierarchical, with each system operating at varying degrees of abstraction in relation to the immediate physical world. In this talk, I will describe how experiments in my laboratory focused on understanding how neural circuits are provided a temporal basis computation have revealed not only fundamental principles underlying temporal processing, but also signatures of how hierarchies of representations can interact to produce robust policies for behavior, and how distinct aspects of behavioral control appear to be handled by different brain systems.

Joseph J. Paton, PhD

• Champalimaud Research
• Lisboa, Portugal
• Website

The brain, broadly speaking, is for control. 600 million years of evolution has endowed nervous systems with a multitude of mechanisms for achieving that control. In vertebrates, mechanisms in the spinal cord and hindbrain are responsible for more automatized forms of control: reflex circuits, central pattern generators, and circuits for movement primitives. These processes can be selected amongst, modulated, and chained together by the descending influence of brain systems positioned more rostrally that possess a rich capacity to learn from experience. It is these more adaptive systems that my laboratory is most interested in understanding. And yet, control by these systems appears to be fundamentally both heterarchical, requiring distinct computations performed by specific brain systems, and hierarchical, with each system operating at varying degrees of abstraction in relation to the immediate physical world. In this talk, I will describe how experiments in my laboratory focused on understanding how neural circuits are provided a temporal basis computation have revealed not only fundamental principles underlying temporal processing, but also signatures of how hierarchies of representations can interact to produce robust policies for behavior, and how distinct aspects of behavioral control appear to be handled by different brain systems.

Prof. Véronique Deroche-Gamonet

• Neurocentre Magendie
• Université de Bordeaux
• Website